Thermo Fisher Scientific DFFB Monoclonal Antibody (36A349)
인간 DFFB 단백질에 특이적인 mouse IgG1 단클론 항체로 Western blot에 적합합니다. 0.5 mg/mL 농도의 액상 형태이며 Protein G로 정제되었습니다. 단기 4°C, 장기 -20°C에서 보관하며 세포 사멸 관련 CAD 단백질 검출에 활용됩니다.
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Thermo Fisher Scientific DFFB Monoclonal Antibody (36A349)
Applications
- Western Blot (WB): 1:100–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 36A349 |
| Immunogen | Anti-DFF40 monoclonal antibody was raised against a peptide corresponding to amino acids 205–222 (SYFDRGAKGGSRLCTPEG) of human DFF40. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1954959 |
Product Specific Information
MA1-91618 detects CAD from human samples.
Target Information
Caspase-activated DNase (CAD) cleaves chromosomal DNA during apoptosis. Apoptosis, a programmed cell death process that removes toxic or unnecessary cells, can be induced by various stimuli such as tumor necrosis factors, UV irradiation, anticancer drugs, and deprivation of survival factors.
During apoptosis, cells and nuclei shrink and fragment, and chromosomal DNA is degraded into nucleosomal units. CAD, activated by caspases, exists as a complex with its inhibitor ICAD. ICAD assists in the proper folding of CAD and inhibits its DNase activity.
When caspases are activated, they cleave ICAD, releasing CAD to enter the nucleus and degrade chromosomal DNA. The activation of caspases is regulated by the balance between pro- and anti-apoptotic proteins of the Bcl-2 family, heat shock proteins, and inhibitors of apoptosis proteins (IAPs).
Currently, fourteen members of the caspase family have been identified, seven of which mediate apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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