Thermo Fisher Scientific SNAI-1 Polyclonal Antibody
SNAI-1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P) 실험에 사용 가능. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제되었으며, 0.5 mg/mL 농도의 액상 형태로 제공. 핵 및 세포질 내 발현 검출에 적합.
- 카탈로그번호
- 630-710
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide EL TSL SDE DSG KGS QPP SPP SP corresponding to human SNAI-1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: HeLa whole cell lysate
- Cellular location: Nucleus and cytoplasm
Target Information
Zinc finger protein SNAI1 (SNAIL) is a zinc finger transcriptional repressor that downregulates ectodermal gene expression within the mesoderm and plays a role in mesoderm and neural crest formation.
SNAI1 is an important factor in tumor invasion due to its role in E-cadherin down-regulation and induction of epithelial-mesenchymal transition (EMT).
In human breast cancer, expression of SNAI1 and/or SNAI2 (Slug) has been associated with E-cadherin repression, metastasis, tumor recurrence, or poor prognosis.
Snail 1 protein in the stroma may serve as a potential prognostic marker for colon tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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