Thermo Fisher Scientific SNAIL-1, 2, 3 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.1-1 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

2-10 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide SR AFA DRS NLR AHL QTH corresponding to human SNAI protein. It is identical to human, mice and rat. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SNAIL 1/2/3,uniProtId:O95863-1,ncbiNodeId:9606,antigenRange:214-230,antigenLength:264,antigenImageFileName:630-740_SNAIL_123_O95863-1_Rabbit.svg,antigenImageFileNamePDP:630-740_SNAIL_123_O95863-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with proprietary stabilizer

Contains

0.01% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Positive control: HeLa whole cell lysate

Cellular location: Nucleus and cytoplasm.

Target Information

The Snail family of zinc-finger transcription factors consist of Snail1 (Snail), Snail2 (Slug) and Snail3 (Smuc), which shares an evolutionary conserved role in mesoderm formation in vertebrates. These molecules are composed of a highly conserved carboxy-terminal region containing four to six C2H2-type zinc fingers, which mediate sequence-specific interactions with DNA promoters containing an E-box sequence (CAGGTG). The amino termini of all vertebrate Snail family members contain the evolutionarily conserved SNAG (Snail/Gfi) domain, which is essential for transcriptional repression. Drosophila Snail lacks a SNAG domain; it has a consensus PxDLSx motif and exerts its repressive function through the interaction with the co-repressor CtBP. (PubMed: 20168078)

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.