Thermo Fisher Scientific SNAIL-1, 2, 3 Polyclonal Antibody
SNAIL-1, 2, 3에 특이적인 Rabbit Polyclonal Antibody로 인간, 마우스, 랫트 반응성. WB 및 IHC(P) 응용 가능. 항원 친화 크로마토그래피로 정제된 액상 형태. 핵 및 세포질 위치 검출에 적합하며 연구용으로 사용.
- 카탈로그번호
- 630-740
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 0.1–1 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 2–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide SR AFA DRS NLR AHL QTH corresponding to human SNAI protein. It is identical to human, mice and rat. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: HeLa whole cell lysate
- Cellular location: Nucleus and cytoplasm
Target Information
The Snail family of zinc-finger transcription factors consists of Snail1 (Snail), Snail2 (Slug), and Snail3 (Smuc), which share an evolutionarily conserved role in mesoderm formation in vertebrates.
These molecules contain a carboxy-terminal region with four to six C2H2-type zinc fingers mediating DNA promoter interactions at E-box sequences (CAGGTG).
The amino termini of vertebrate Snail family members have a conserved SNAG domain essential for transcriptional repression.
Drosophila Snail lacks this domain but has a PxDLSx motif and represses transcription via the co-repressor CtBP.
(PubMed: 20168078)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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