Thermo Fisher Scientific PXMP2 Polyclonal Antibody
Thermo Fisher Scientific의 PXMP2 Polyclonal Antibody는 인간 및 랫트 시료에 반응하며 Western blot에 적합합니다. 항원 친화 크로마토그래피로 정제된 고순도 항체로, peroxisomal membrane protein 2(PXMP2)를 인식합니다. 연구용으로 사용되며 장기 보관 시 -20°C에서 안정적입니다.
- 카탈로그번호
- PA575898
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues in Human PXMP2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2719626 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
Peroxisomes are subcellular organelles essential for lipid metabolism, present in nearly all eukaryotic cells. The peroxisomal membrane contains integral and peripheral membrane proteins responsible for importing matrix proteins and transporting metabolites.
Pxmp2 (Peroxisomal membrane protein 2), also known as PMP22, is a 195-amino-acid multi-pass membrane protein belonging to the PXMP2/4 family. It interacts with Peroxin 19 and Siva proteins. Peroxin 19 is required for peroxisome membrane synthesis and binds multiple peroxisomal membrane proteins (PMPs).
Pxmp2 is the most abundant peroxisomal membrane protein in higher eukaryotes, with tissue-specific expression highest in liver, kidney, and heart. It is suggested to have pore-forming activity contributing to peroxisomal membrane permeability. Disruption of the Pxmp2 gene in mice restricts peroxisomal membrane permeability to solutes. The Pxmp2 gene is conserved across multiple species and maps to human chromosome 12q24.33.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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