Thermo Fisher Scientific Lactotransferrin/Lactoferrin/LTF Monoclonal Antibody (LTF/4079)
인간 Lactotransferrin(Lactoferrin, LTF)을 인식하는 Mouse monoclonal antibody. IHC, ICC/IF, Flow Cytometry 등 다양한 응용 가능. Recombinant fragment(aa614-645)을 면역원으로 사용. 고순도 Protein A/G 정제, 1 mg/mL 농도의 액상형 제품.
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Applications 및 권장 희석 배율
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | LTF/4079 |
| Immunogen | Recombinant fragment (around aa614–645) of human Lactotransferrin protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Lactoferrin (LF) is an iron-binding glycoprotein composed of a single polypeptide chain (~80 kDa) folded into two homologous lobes, each capable of reversibly binding one ferric ion (Fe³⁺). It is found in external fluids such as milk and mucosal secretions and is a key component of neutrophil secondary granules.
LF plays roles in iron homeostasis, host defense against microbial infections, anti-inflammatory activity, cellular growth regulation, and protection against cancer development and metastasis.
LTF acts as a major first-line defense against microbial infections by binding and removing Fe³⁺ and also exhibits bactericidal and proteolytic activity.
Three isoforms (LTF-α, LTF-β, LTF-γ) have been identified, and LTF receptors are expressed in the gastrointestinal tract, macrophages, lymphocytes, neutrophils, platelets, and some bacteria.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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