Thermo Fisher Scientific CD8 Recombinant Mouse Monoclonal Antibody (RIV11)

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: Assay-dependent

Flow Cytometry (Flow)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

Specificity: This antibody recognizes human CD8, a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8α/β) or as a homodimer (CD8α/α). CD8 acts as a T-cell co-receptor involved in the recognition of MHC class I molecules and is present on cytotoxic/suppressor T lymphocytes.

Target Information

Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin family that plays an integral role in signal transduction, T-cell differentiation, and activation.
CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with TCR for MHC class I molecules.
It is also expressed on subsets of T cells, NK cells, monocytes, and dendritic cells as homodimers of CD8α.
Ligation of MHC-I/peptide complexes triggers recruitment of Lck kinase, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation.
Activated CTLs play a crucial role in pathogen and tumor cell clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.