Thermo Fisher Scientific ALOX5 Monoclonal Antibody (OTI1C1), TrueMAB
ALOX5 단백질을 표적으로 하는 Mouse IgG1 단일클론 항체로, WB 및 IHC(P) 실험에 적합합니다. 인간 반응성, 비결합형, 동결건조 형태이며, 고순도 친화 크로마토그래피로 정제되었습니다. 염증 반응 및 류코트리엔 합성 연구에 활용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1C1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 18–364 of human ALOX5 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step.
Recommended reagent: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
The ALOX5 gene encodes a protein that, together with arachidonate 5-lipoxygenase-activating protein, is required for leukotriene synthesis.
Leukotrienes are arachidonic acid metabolites involved in inflammatory responses such as asthma, arthritis, and psoriasis.
This protein localizes to the plasma membrane. Inhibitors of ALOX5 impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit its activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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