Thermo Fisher Scientific ADM Monoclonal Antibody (OTI8A1), TrueMAB
인간 ADM 단백질(아드레노메둘린)을 인식하는 마우스 단클론 항체. IHC(P) 검증 완료, 비결합형 동결건조 형태. 친화 크로마토그래피 정제 및 트레할로스 함유 PBS 보존. 연구용으로 혈관 확장 및 체액 항상성 연구에 적합.
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Applications
Tested Application
- Immunohistochemistry (Paraffin) (IHC (P)): 1:250
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8A1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 22–146 of human ADM produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Adrenomedullin (ADM) is a vasodilator produced by most contractile cells and is characterized by persistent hypotensive activity. It plays a role in regulating fluid and electrolyte homeostasis and maintaining cardiovascular function. ADM levels are elevated in hypertensive patients and contribute to natriuresis, particularly after aneurysmal subarachnoid hemorrhage. ADM promotes natriuresis by increasing glomerular filtration rate and decreasing distal tubular sodium reabsorption. It is present in both peripheral tissues and the brain, where it can reduce food intake.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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