Thermo Fisher Scientific RANKL Chimeric Recombinant Rabbit Monoclonal Antibody (IK22-5)
RANKL에 특이적인 재조합 토끼 단클론 항체로, 마우스 시료에 반응합니다. IHC, Flow Cytometry, Neutralization 등 다양한 응용에 적합합니다. HEK293 세포에서 발현되었으며 Protein A로 정제된 고순도 항체입니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific RANKL Chimeric Recombinant Rabbit Monoclonal Antibody (IK22-5)
Applications
- Immunohistochemistry (IHC): Assay-dependent
- Flow Cytometry (Flow): Assay-dependent
- Neutralization (Neu): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | IK22-5 |
| Immunogen | This antibody was raised by immunising an SD rat with murine RANKL-transfected baby hamster kidney cells. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074627 |
Product Specific Information
Specificity: This antibody is specific for murine RANKL.
Target Information
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. It acts as a dendritic cell survival factor and regulates T cell-dependent immune responses. T cell activation induces expression of this gene, promoting osteoclastogenesis and bone loss. It activates antiapoptotic kinase AKT/PKB via a signaling complex involving SRC kinase and TRAF6, suggesting a role in apoptosis regulation. Knockout mice show severe osteopetrosis, lack of osteoclasts, and defects in T/B lymphocyte differentiation and mammary gland development. Two alternatively spliced transcript variants have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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