Thermo Fisher Scientific FceR1 alpha Chimeric Recombinant Rabbit Monoclonal Antibody (Mar-1)
FcεR1 alpha 체인을 특이적으로 인식하는 재조합 토끼 단클론 항체로, IHC, Flow Cytometry, IP 등 다양한 응용에 사용 가능. HEK293 발현 시스템 기반, Protein A 정제, 비결합형 액상 형태. 알레르기 반응 연구용에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | Assay-dependent |
| Flow Cytometry (Flow) | 1:100 |
| Immunoprecipitation (IP) | Assay-dependent |
| Functional Assay | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG, lambda |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Mar-1 |
| Immunogen | Proprietary sequence |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074629 |
Product Specific Information
This antibody specifically targets the non-signalling alpha chain of the FceR1 complex.
Target Information
FceR1 (Fc epsilonR1 alpha) is a subunit of the high-affinity receptor for IgE. It forms a tetrameric complex consisting of one alpha, one beta, and two additional subunits required for signal transduction. The Fc epsilonR1 complex plays a key role in triggering allergic responses. When allergen-bound IgE molecules cross-link multiple receptors, mediators such as histamine are released, initiating inflammatory responses typical of allergies such as hay fever and asthma. The release of histamine and proteases induces synthesis of prostaglandins and leukotrienes, which are potent effectors of hypersensitivity reactions.
Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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