Thermo Fisher Scientific CD66 Chimeric Recombinant Rabbit Monoclonal Antibody (A5B7)
인간 CEA에 특이적인 재조합 토끼 단클론항체로, IHC, 기능 분석 및 RIA에 사용 가능. HEK293 세포에서 발현된 IgG 카파형 항체이며, Protein A로 정제됨. 액상 형태로 제공되며, 4°C 단기 보관 및 -20°C 장기 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | Assay-dependent |
| Functional Assay | Assay-dependent |
| Radioimmune Assays (RIA) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | A5B7 |
| Immunogen | This antibody was raised by immunising mice with both carcinoembryonic antigen (CEA) purified from the metastases of colonic tumours, and heat-treated CEA. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_3074624 |
Product Specific Information
Specificity: This antibody is specific for human CEA.
Target Information
The CD66 molecules are 180–200 kDa glycoproteins of the carcinoembryonic antigen family. They are present on all blood granulocytes and some tissue macrophages, but are absent from other hematopoietic cells. The expression of CD66 increases significantly on granulocytes upon their activation.
CD66a (BGP1, CEACAM1) and CD66d (CGM1, CEACAM3), as well as CEACAM2 and 4, are transmembrane proteins, whereas CD66c (CEAL, NCA, CEACAM6) and CD66e (CEA, CEACAM5), as well as CEACAM7 and 8, are anchored to the plasma membrane by a C-terminal glycosylphosphatidylinositol (GPI) lipid moiety.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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