Thermo Fisher Scientific RANKL Recombinant Rat Monoclonal Antibody (IK22-5)
RANKL 특이적 랫트 재조합 단클론 항체로, 마우스 시료에 반응합니다. IHC, Flow Cytometry, Neutralization 등 다양한 어세이에 사용 가능합니다. Protein A로 정제된 액상 형태이며, 장기 보관 시 -20°C에서 냉동 보관 권장.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: Assay-dependent
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
Neutralization (Neu)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | IK22-5 |
| Immunogen | This antibody was raised by immunising an SD rat with murine RANKL-transfected baby hamster kidney cells. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074628 |
Product Specific Information
- Specificity: This antibody is specific for murine RANKL.
Target Information
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation.
It acts as a dendritic cell survival factor and regulates T cell-dependent immune responses. T cell activation induces its expression, leading to increased osteoclastogenesis and bone loss.
This protein activates anti-apoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and TRAF6, suggesting a role in apoptosis regulation.
Targeted disruption in mice causes severe osteopetrosis and absence of osteoclasts, with defects in early T/B lymphocyte differentiation and impaired mammary gland development during pregnancy.
Two alternatively spliced transcript variants have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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