Thermo Fisher Scientific RANKL Recombinant Rat Monoclonal Antibody (IK22-5)

Applications

Immunohistochemistry (IHC)

• Tested Dilution: Assay-dependent

Flow Cytometry (Flow)

• Tested Dilution: Assay-dependent

Neutralization (Neu)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• Specificity: This antibody is specific for murine RANKL.

Target Information

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation.
It acts as a dendritic cell survival factor and regulates T cell-dependent immune responses. T cell activation induces its expression, leading to increased osteoclastogenesis and bone loss.
This protein activates anti-apoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and TRAF6, suggesting a role in apoptosis regulation.
Targeted disruption in mice causes severe osteopetrosis and absence of osteoclasts, with defects in early T/B lymphocyte differentiation and impaired mammary gland development during pregnancy.
Two alternatively spliced transcript variants have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.