Thermo Fisher Scientific Chk1 Monoclonal Antibody (T.59.2)
Chk1 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot에 적합합니다. Human, Mouse, Rat 등 다양한 종에 반응하며, DNA 손상 반응 연구 및 세포주기 조절 기전 연구에 활용됩니다. 액상 형태로 -20°C 보관합니다.
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Thermo Fisher Scientific Chk1 Monoclonal Antibody (T.59.2)
Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
Publications: - [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | T.59.2 |
| Immunogen | Purified recombinant Chk1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 168 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10984221 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised. CHK1 acts as a key mediator in the DNA damage-induced checkpoint network and maintains genomic integrity under genotoxic stress. Inhibition of CHK1 can lead to mitotic catastrophe and apoptosis in p53-deficient cancer cells, while normal cells remain arrested in the G1 phase. Therefore, CHK1 is an attractive therapeutic target for cancer treatment, particularly in p53-deficient tumors.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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