Thermo Fisher Scientific IRS1 Monoclonal Antibody (K.346.8)
IRS1 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, Western blot 및 Immunocytochemistry에 적합. 인간, 생쥐, 랫드 반응성. IRS-2와 교차 반응하지 않으며, 액상 형태로 -20°C 보관. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
- View 2 publications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100
- View publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Pig |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | K.346.8 |
| Immunogen | Synthetic peptide corresponding to the sequence surrounding Ser307 of human IRS-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 84 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10988670 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with IRS-2.
Target Information
IRS-1 is a major substrate of the insulin receptor and is phosphorylated in response to stimulation by insulin, IGF-1, and IL-4. It undergoes phosphorylation on serine, threonine, and tyrosine residues across various tissues. Casein kinase II mediates insulin-stimulated serine/threonine phosphorylation of IRS-1, with Thr502 and Ser99 identified as major phosphorylation sites. IRS-1 also contains three putative 14-3-3 binding sites (Ser270, Ser374, Ser641), with the Ser270 motif located in the phosphotyrosine binding domain responsible for insulin receptor interaction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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배송/결제/교환/반품 안내
배송 정보
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