Thermo Fisher Scientific PP2A alpha Monoclonal Antibody (F.451.5)
PP2A alpha 단백질 인산화 조절 연구용 항체. Western blot, IHC, ICC/IF, IP에 사용 가능. Rabbit monoclonal 항체로 높은 특이성과 재현성 제공. 인간, 생쥐, 랫드 등 다양한 종에 반응. 연구용으로만 사용.
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:25 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Immunoprecipitation (IP) | 1:25 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Fruit fly, Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | F.451.5 |
| Immunogen | Synthetic peptide corresponding to the sequence of human PP2A C subunit protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 16 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10984911 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with other PP2A subunits.
Target Information
In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential mechanism regulating cellular functions such as division, homeostasis, and apoptosis. Protein phosphatases are key enzymes in this process, generally forming trimeric complexes composed of regulatory, variable, and catalytic subunits. Four major families of protein phosphatase catalytic subunits have been identified: PP1, PP2A, PP2B (calcineurin), and PP2C. The PP2A family includes PP2A alpha and PP2A beta subunits. Another related phosphatase, PPX (also known as PP4), is considered part of a novel PP family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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