Thermo Fisher Scientific Factor VIII Recombinant Rabbit Monoclonal Antibody (226)

Applications

ELISA

• Tested Dilution: 1:5,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning the specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire

This antibody has specificity for Human Coagulation Factor VIII/FVIII/F8 Heavy Chain.

Target Information

This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation. Factor VIII acts as a cofactor for factor IXa, which, in the presence of Ca²⁺ and phospholipids, converts factor X to the activated form Xa.
Two alternatively spliced transcripts are produced:

1. Transcript variant 1: Encodes a large glycoprotein (isoform a) that circulates in plasma and associates with von Willebrand factor in a noncovalent complex.
2. Transcript variant 2: Encodes a smaller protein (isoform b) consisting primarily of the phospholipid binding domain, essential for coagulant activity.

Defects in this gene result in Hemophilia A, a common recessive X-linked coagulation disorder.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.