Thermo Fisher Scientific IFN gamma Monoclonal Antibody (4S.B3), eBioscience
인간 IFN-γ를 인식하는 단클론 항체로, IHC, ICC, Flow Cytometry, ELISA, Neutralization 등에 사용 가능. 4S.B3 클론, Mouse IgG1, kappa 타입으로 높은 순도(>90%)와 낮은 응집도(<10%)를 보유. 다양한 형광 및 효소 결합 형식 제공.
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Thermo Fisher Scientific IFN gamma Monoclonal Antibody (4S.B3), eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Flow Cytometry (Flow) | Assay-Dependent | View 100 publications |
| ELISA | - | View 3 publications |
| Neutralization | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse, Rat, Rhesus monkey |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4S.B3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_468477 |
Available Conjugate Formats
- Alexa Fluor 488
- Alexa Fluor 660
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Biotin
- Brilliant UV 395 / 496 / 615 / 661 / 737 / 805
- Brilliant Violet 650
- eFluor 450 / 506 / 660
- FITC
- PE / PE-Cyanine7 / PE-eFluor 610
- PerCP-Cyanine5.5
- Custom conjugation available
Product Specific Information
The 4S.B3 monoclonal antibody reacts with interferon-gamma (IFN gamma). Human IFN gamma is a 17 kDa cytokine produced by activated T and NK cells, exhibiting antiviral and antiparasitic activity. It synergizes with TNF alpha to inhibit proliferation of normal and transformed cells.
Unlabeled 4S.B3 has been used as a cold mAb control to block fluorochrome-conjugated 4S.B3 in intracellular staining assays.
Purity is greater than 90% (SDS-PAGE), aggregation less than 10% (HPLC), and the product is filtered through 0.2 µm.
Target Information
Interferon gamma (IFN-γ, Type II interferon) is a macrophage activation factor produced mainly by T lymphocytes and NK cells. It is a dimeric glycoprotein (~45 kDa) composed of two 146 amino acid subunits.
Functions include:
- Antiviral and tumor antiproliferative activity
- Induction of MHC class I and II
- Macrophage activation
- Enhanced immunoglobulin secretion by B cells
Human IFN-γ does not cross-react with mouse IFN-γ. It activates the JAK-STAT pathway via IFN-γ receptor I and II. Mutations in the IFN-γ gene are associated with aplastic anemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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