Thermo Fisher Scientific p21WAF1 (Tumor Suppressor Protein) Monoclonal Antibody (rCIP1/6907)
인간 p21WAF1 종양 억제 단백질을 인식하는 마우스 단클론 항체. IHC(P), IHC(PFA) 실험에 적합하며, Protein A/G로 정제된 액상 형태. PBS(pH 7.4) 버퍼에 보존되며 방부제 무첨가. 세포 주기 조절 및 DNA 손상 반응 연구에 유용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | rCIP1/6907 |
| Immunogen | Recombinant fragment (around aa1–100) of human p21 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
Protein p21 is a tumor suppressor protein that inhibits cyclin-dependent kinases (CDK) and is transcriptionally activated by p53. It plays a key role in the cellular response to genotoxic stress and is a major transcriptional target of p53. Nuclear p21 binds and inhibits Cdk1 and Cdk2, blocking the transition from G1 to S phase or from G2 to mitosis after DNA damage, allowing repair of damaged DNA. In the cytoplasm, p21 exhibits anti-apoptotic activity by binding to and inhibiting caspase 3, ASK1, and JNK. Thus, p21 has dual roles in carcinogenesis, acting as both a tumor suppressor and an oncogene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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