Thermo Fisher Scientific p21WAF1 (Tumor Suppressor Protein) Monoclonal Antibody (WA-1)
Tumor suppressor protein p21(WAF1) 검출용 WA-1 단클론 항체로, 인간 및 다양한 종에 반응. IHC, ICC/IF, Flow cytometry 등 다양한 응용에 적합. p53 경로 연구 및 세포주기 조절 메커니즘 분석에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Chimpanzee, Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | WA-1 |
| Immunogen | Human recombinant p21 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Protein p21 is a tumor suppressor protein that inhibits Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53. It plays a crucial role in the cellular response to genotoxic stress and is a major transcriptional target of p53.
In the nucleus, p21 binds to and inhibits Cdk1 and Cdk2, blocking cell cycle transitions (G1 to S phase and G2 to mitosis) after DNA damage, facilitating DNA repair.
In the cytoplasm, p21 exhibits anti-apoptotic activity by inhibiting caspase 3, ASK1, and JNK.
It has dual roles in carcinogenesis—acting both as a tumor suppressor and as an oncogene depending on cellular context.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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