Thermo Fisher Scientific ADAM10 Recombinant Rabbit Monoclonal Antibody (JM32-11)
ADAM10 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot 및 Immunoprecipitation에 적합합니다. 높은 특이성과 재현성을 제공하며, 로트 간 일관성이 우수합니다. 단백질 A로 정제된 액상 형태로, 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 1–2 µg/sample |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JM32-11 |
| Immunogen | Synthetic peptide within Human ADAM10 aa 715–748 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809893 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and screened to select the best candidates for production.
Advantages include:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broad immunoreactivity due to larger rabbit immune repertoire
Target Information
The proinflammatory cytokine TNF-α contributes to inflammatory responses and programmed cell death. Notch receptor and its ligand are involved in cell fate decisions during vertebrate development and are associated with several human disorders, including T-cell lymphoma.
TNF-α, Notch, and its ligand delta are membrane-bound molecules cleaved by proteases to release mature proteins or functional receptors.
ADAM10, a metalloprotease-disintegrin of the ADAM family, cleaves TNF-α, Notch, and delta ligands. The genes encoding human, mouse, and bovine ADAM10 have been cloned and are expressed in various tissues.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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