Thermo Fisher Scientific IL-23 p19 Monoclonal Antibody (320234)
Thermo Fisher Scientific의 IL-23 p19 단클론 항체(320234)는 Mouse IL-23 p19 서브유닛을 인식합니다. Western blot 및 ELISA에 적합하며, 높은 특이성과 재현성을 제공합니다. 단백질 A/G로 정제된 Lyophilized 형태로, PBS 및 5% trehalose buffer에 보관됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| ELISA (Detection) | 0.1–0.4 µg/mL |
| ELISA (Capture) | 2–8 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 320234 |
| Immunogen | E. coli-derived recombinant mouse IL-23 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2605570 |
Product Specific Information
This antibody recognizes an epitope in the p19 subunit of IL-23.
In ELISAs, it does not cross-react with recombinant mouse IL-23 p19, IL-23 R, IL-12 R beta, IL-12 p35, recombinant human IL-23, IL-23 p19, recombinant rat IL-12, IL-12 p40, IL-12 p40 homodimer, or IL-12.
Reconstitution: Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
IL-23 is a heterodimeric cytokine composed of the p40 subunit of IL-12 disulfide-linked with a protein p19.
The p19 subunit, like p35 of IL-12, is biologically inactive by itself. IL-23 interacts with IL-12Rβ1 and an additional receptor subunit termed IL-23R, which contains a STAT4 binding domain.
IL-23 is secreted by activated mouse and human dendritic cells.
Biological activities of mouse IL-23 differ from those of mouse IL-12:
- IL-23 does not induce significant IFN-γ production.
- IL-23 induces strong proliferation of memory T cells (not naïve T cells).
- IL-23 activates mouse memory T cells to produce proinflammatory cytokine IL-17.
In humans, IL-23 induces proliferation of memory T cells and moderate IFN-γ production by naïve and memory T cells, compared to IL-12.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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