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Thermo Fisher Scientific IL-10 Monoclonal Antibody (JES052A5)
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마우스 IL-10에 특이적인 단클론 항체로, Western blot, ELISA, Flow cytometry, Neutralization 등 다양한 응용에 사용 가능. 낮은 내독소 수준(<0.10 EU/µg)과 높은 특이성을 지님. 단백질 A/G 정제, 동결건조 형태로 제공되며 -20°C에서 보관.
- 판매단위
- pk
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마지막 업데이트 2025. 07. 31. 오후 02:05
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Thermo Fisher Scientific MA523796 IL-10 Monoclonal Antibody (JES052A5) 500 ug pk판매 단위 pk ·
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722,400원VAT 포함 794,640원
Thermo Fisher Scientific · Thermo Fisher Scientific IL-10 Monoclonal Antibody (JES052A5)
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | View 1 publication |
| Flow Cytometry (Flow) | - | View 5 publications |
| ELISA | 0.1–0.4 µg/mL (Detection), 2–8 µg/mL (Capture) | View 2 publications |
| Neutralization (Neu) | 0.005–0.015 µg/mL | View 1 publication |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Human |
| Host / Isotype | Rat / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | JES052A5 |
| Immunogen | E. coli-derived recombinant mouse IL-10 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609275 |
Product Specific Information
- In sandwich ELISAs, less than 8% cross-reactivity with recombinant rat IL-10 and 1% with recombinant cotton rat IL-10 is observed.
- No cross-reactivity with recombinant human IL-10, mouse IL-10 R, human IL-10 R, canine IL-10, feline IL-10, or porcine IL-10.
- Reconstitute at 0.5 mg/mL in sterile PBS.
- Endotoxin level: <0.10 EU per 1 µg of antibody (LAL method).
Target Information
IL-10 encodes a cytokine primarily produced by monocytes and some lymphocytes. It plays a key role in immunoregulation and inflammation by:
- Down-regulating Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages
- Enhancing B cell survival, proliferation, and antibody production
- Blocking NF-kappa B activity
- Regulating the JAK-STAT signaling pathway
Knockout studies indicate IL-10 is critical for intestinal immune regulation. Mutations are linked to increased susceptibility to HIV-1 infection and rheumatoid arthritis.
Associated diseases include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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