Thermo Fisher Scientific AKT1 Monoclonal Antibody (14E5.A2.B2.H9), Biotin

Applications

Product Specifications

Additional Formats

• Unconjugated
• APC
• FITC
• PE
• Request custom conjugation

Product Specific Information

Store vial at 4°C prior to restoration. Restore with deionized water (or equivalent).
For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing.
Centrifuge product if not completely clear after standing at room temperature.
Stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.
Expiration date is one (1) year from date of restoration.

Anti-AKT1 antibody is directed against human AKT1. The antibody detects both unphosphorylated and phosphorylated forms of the protein.
Cross-reactivity with AKT1 from other species has not been determined; however, the sequence of the immunogen shows 85% identity to mouse and 92% identity with rat, therefore, cross-reactivity is expected.

Target Information

AKT1 (PKB alpha) is a serine/threonine kinase that regulates cell survival. The activated enzyme inhibits apoptosis and stimulates cell cycle progression by phosphorylating numerous targets in various cell types, including cancer cells.
This protein kinase is activated by insulin, PI3K, IGF1, and various other growth and survival factors.
Akt promotes cell survival by inhibiting apoptosis through phosphorylation and inactivation of several targets, including forkhead transcription factors and caspase-9.
The AKT pathway is a major target for cancer drug discovery.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.