Thermo Fisher Scientific GABRA6 Polyclonal Antibody
GABRA6 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot에 적합. Mouse와 Rat에서 반응. KLH에 결합된 합성 펩타이드 면역원 사용. 0.15 mg/mL 농도, 액상 형태로 -20°C 보관. 연구용으로만 사용 가능.
- 카탈로그번호
- OPA104114
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific GABRA6 Polyclonal Antibody
Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acid residues specific to the alpha 6 subunit of rat GABRA6 conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.15 mg/mL |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_325091 |
Product Specific Information
In Western blot, this antibody detects a ~57 kDa protein representing the GABA-A R alpha 6 subunit in rat brain lysate.
The immunogenic sequence has no homology with any other GABA-A receptor subunits.
Target Information
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing hyperpolarization of the membrane through the opening of a Cl⁻ channel associated with the GABA-A Receptor (GABA-A R) subtype.
GABA-A Rs are important therapeutic targets for sedative, anxiolytic, and hypnotic agents, and are implicated in diseases including epilepsy, anxiety, depression, and substance abuse.
The GABA-A R is a multimeric subunit complex composed of multiple alpha, beta, and gamma subunits, including splicing variants.
Expression of alpha and beta subunits results in functional GABA-A Rs sensitive to GABA, while coexpression of a gamma subunit is required for benzodiazepine modulation.
Phosphorylation of beta subunits has been shown to modulate GABA-A R function.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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