Thermo Fisher Scientific Tyrosine Hydroxylase Polyclonal Antibody
Tyrosine Hydroxylase 단백질을 검출하는 Rabbit Polyclonal 항체로, WB, IHC, ICC 등 다양한 응용에 적합. Human, Mouse, Rat 시료에 반응하며, 친화 크로마토그래피로 정제된 액상 형태. 도파민성 뉴런 연구 및 파킨슨병 관련 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 4 publications |
| Immunohistochemistry (IHC) | 1:1,000 | View 9 publications |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | - | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:1,000 | View 2 publications |
| Immunohistochemistry - Free Floating (IHC (Free)) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:1,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Many, Mouse, Rat |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | SDS-denatured, native rat tyrosine hydroxylase purified from pheochromocytoma |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.15 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 0.1mg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_325653 |
Product Specific Information
In Western blot, this antibody detects a single ~60 kDa protein representing tyrosine hydroxylase from rat brain lysates or PC-12 cells stimulated by okadaic acid.
Immunohistochemical staining of TH in human brain with OPA1-04050 results in intense labeling of dopaminergic neurons in the substantia nigra.
Store at -20°C for short term, -80°C for long term.
Target Information
Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters such as dopamine, epinephrine, and norepinephrine. Catecholamine synthesis is regulated by the interaction of TH with the cofactor tetrahydrobiopterin (BH4), which binds to the TH catalytic domain to activate the enzyme.
In humans, four TH mRNA splice variants (hTH1–hTH4) have been identified, differing in their N-terminal regulatory domains.
TH catalyzes the conversion of L-tyrosine to L-dopa and plays a key role in adrenergic neuron physiology.
Its function is linked to several neuropathogenic diseases, including Parkinson’s disease, schizophrenia, Segawa syndrome, dystonia, and various cardiovascular diseases.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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