Thermo Fisher Scientific Phospho-TPL2 (Ser443) Polyclonal Antibody
MAP3K8/COT 단백질의 Ser443 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 사용 가능. Human, Mouse, Rat 반응성. 고순도 정제, 액상 형태로 -20°C 보관.
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Thermo Fisher Scientific Phospho-TPL2 (Ser443) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MAP3K8/COT around the phosphorylation site of Ser443 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899236 |
Product Specific Information
Antibody detects endogenous levels of MAP3K8/COT only when phosphorylated at Ser443.
Target Information
MAP3K8 (COT) is a serine/threonine kinase that activates both MAP and JNK kinase pathways and plays a role in the cell cycle.
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK (ERK), MAPK kinase (MEK), and MAPK kinase kinase (MEKK).
MEKK phosphorylates and activates its downstream kinase MEK, which in turn activates MAPK.
These signaling cascades are highly conserved across species.
MEKK8 can activate NF-kappa-B1 by stimulating proteasome-mediated proteolysis of NF-kappa-B1/p105.
This cytoplasmic protein is expressed in several normal tissues and tumor-derived cell lines.
The 58 kDa form is activated during S and G2/M phases of the cell cycle.
The longer form undergoes phosphorylation mainly on Ser residues, and the shorter form on both Ser and Thr residues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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