Thermo Fisher Scientific Phospho-TSC2 (Thr1462) Polyclonal Antibody
TSC2 단백질의 Thr1462 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 사용 가능. Human, Mouse, Rat 반응성. 1 mg/mL 농도의 액상 제품으로 -20°C 보관.
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Thermo Fisher Scientific Phospho-TSC2 (Thr1462) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TSC2 (Accession P49815), corresponding to amino acid residues around phosphorylated Thr1462 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816389 |
Product Specific Information
Antibody detects endogenous levels of Tuberin/TSC2 only when phosphorylated at Threonine 1462.
Target Information
TSC2 (Tuberin, Tuberous sclerosis complex, TSC Complex Subunit 2) is a tumor suppressor protein involved in the regulation of cell growth, vesicular transport, and transcription mediated by steroid receptors.
TSC2 forms a cytosolic complex with hamartin (TSC1), acting as a chaperone and regulating its interaction through phosphorylation at Ser939 and Thr1462 via the PI3K/Akt pathway.
Mutations in TSC2 can lead to constitutive activation of RAP1A and are associated with diseases such as lymphangioleiomyomatosis and TSC2 angiomyolipoma.
Alternative splicing produces multiple isoforms of TSC2.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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