Thermo Fisher Scientific Phospho-p130Cas (Tyr249) Polyclonal Antibody
Phospho-p130Cas (Tyr249) 폴리클로날 항체로 인산화된 p130Cas 단백질을 특이적으로 검출. Western blot, IHC, ICC/IF 등 다양한 응용 가능. Rabbit IgG 기반, 1 mg/mL 농도. 인산화 신호 전달 및 세포 부착 연구에 적합.
- 카탈로그번호
- PA5104624
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BCAR1 (Accession P56945), corresponding to amino acid residues around phosphorylated Tyr249 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816099 |
Product Specific Information
This antibody detects endogenous levels of p130Cas only when phosphorylated at Tyr249.
Target Information
The p130Cas (Cas for Crk-associated substrate) is a common cellular target of phosphorylation signals via v-Crk and v-Src oncoproteins.
It contains an SH3 domain followed by multiple YXXP motifs and a proline-rich region.
p130Cas is involved in key biological processes such as:
- Cell adhesion and migration
- Growth factor stimulation
- Cytokine receptor engagement
- Bacterial infection
Physiological roles include cardiovascular development, actin filament assembly, and Src-induced cell transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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