Thermo Fisher Scientific Phospho-NPM1 (Thr95) Polyclonal Antibody
Phospho-NPM1 (Thr95) 폴리클로날 항체로, 인산화된 NPM1 단백질의 Thr95 잔기를 특이적으로 검출합니다. Western blot 및 IHC(P) 실험에 적합하며, 인간, 마우스, 랫트 시료에 반응합니다. 고순도의 정제 항체로 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA5104621
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NPM1 (Accession P06748), corresponding to amino acid residues around phosphorylated Thr95. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816096 |
Product Specific Information
This antibody detects endogenous levels of Nucleophosmin only when phosphorylated at Thr95.
Target Information
NPM1 (Nucleophosmin 1, also known as B23, nutramin, NO38) is a ubiquitously expressed phosphoprotein involved in:
- Ribosome assembly and transport
- Cytoplasmic/nuclear trafficking
- Regulation of DNA polymerase α activity
- Centrosome duplication
- Regulation of p53
NPM1 shuttles between the nucleus, cytoplasm, and nucleolus, acting as a chaperone for core histones. It binds nucleic acids, prevents protein aggregation, and assists in enzyme protection and refolding. NPM1 is associated with centrosome duplication and serves as a substrate for CDK2/cyclin E. It also interacts with tumor-associated fusion proteins (NPM-ALK, NPM-RAR, NPM-MLF1) and can sequester tumor suppressor proteins, such as ARF, within the nucleolus. Dysregulation of NPM1 is linked to diseases including acute myeloid leukemia and lymphomatoid papulosis.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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