Thermo Fisher Scientific Phospho-PAK1/PAK2 (Ser199, Ser204, Ser192, Ser197) Polyclonal Antibody
PAK1 및 PAK2의 인산화된 형태(Ser199/204, Ser192/197)를 검출하는 토끼 폴리클로날 항체. Western blot, IHC, ICC/IF에 적합. 고순도 액상 형태, 1 mg/mL 농도. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PAK1 (Accession Q13153), corresponding to amino acid residues around phosphorylated Ser204. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816103 |
Product Specific Information
Antibody detects endogenous levels of PAK1 when phosphorylated at Ser199/204 or PAK2 when phosphorylated at Ser192/197.
Target Information
Three isoforms of serine/threonine kinases, designated alphaPAK (p68), betaPAK (p65), and gammaPAK (p62), exhibit a high degree of sequence homology with the S. cerevisiae kinase Ste20, which is involved in pheromone signaling.
The alpha, beta, and gammaPAK isoforms specifically complex with Rac1 and Cdc42 in their active GTP-bound state, inhibiting their intrinsic GTPase activity and leading to autophosphorylation.
There are eight sites of autophosphorylation on gammaPAK, including Ser19, Ser141, and Thr402, and phosphorylation of Ser141 and Thr402 correlates with gammaPAK activation.
Once phosphorylated and their affinity for Rac/Cdc42 reduced, the PAK isoforms disassociate from the complex to seek downstream substrates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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