Thermo Fisher Scientific Phospho-VAV1 (Tyr160) Polyclonal Antibody
VAV1 단백질의 Tyr160 인산화 형태를 특이적으로 검출하는 폴리클로날 항체입니다. Western blot, IHC, ICC/IF 등에 사용 가능하며, 인간·마우스·랫트 반응성을 가집니다. 고순도 정제, 액상 형태로 제공되며 연구용으로 적합합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human VAV1 (Accession P15498), corresponding to amino acid residues around phosphorylated Tyr160 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817163 |
Product Specific Information
Antibody detects endogenous levels of VAV1 only when phosphorylated at Tyr160.
Target Information
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. It interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation, or vasoconstriction. Optineurin may also function in cellular morphogenesis, membrane trafficking, vesicle trafficking, and transcription activation through its interactions with RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: PA5-105764_VAV1_P15498-1_Rabbit_PDP.jpeg)
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