Thermo Fisher Scientific Phospho-Chk2 (Ser19) Polyclonal Antibody
Chk2 단백질의 Ser19 인산화 상태를 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot 및 Immunocytochemistry에 적합하며, 높은 특이성과 재현성을 제공. PBS/glycerol buffer에 보관, 연구용으로 사용.
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- PA5105766
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
- Publications: References
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
- Publications: References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CHEK2 (Accession O96017), corresponding to amino acid residues around phosphorylated Ser19 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817165 |
Product Specific Information
This antibody detects endogenous levels of Chk2 only when phosphorylated at Ser19.
Target Information
CHEK2 (CHK2) is a serine/threonine kinase involved in the DNA damage checkpoint pathway. Mutations in CHK2 have been linked to various cancers. CHK2 is activated by DNA damage and phosphorylates several modulators of cell cycle control, including tumor suppressor proteins. It can phosphorylate BRCA1, supporting cell survival after DNA damage. CHK2 acts as a tumor suppressor, and mutations are associated with Li-Fraumeni syndrome, breast cancer, sarcomas, and brain tumors.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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