Thermo Fisher Scientific DLL3 Polyclonal Antibody
DLL3 단백질을 표적으로 하는 Rabbit Polyclonal 항체로, Western Blot 및 IHC에 사용 가능. 인간, 마우스, 영장류 반응성. Protein A 정제 및 PBS buffer에 보관. Notch 신호 경로 연구 및 DLL3 관련 질환 연구에 적합.
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 3–5 µg/mL | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A portion of amino acid 100–150 of human DLL3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2540948 |
Target Information
Delta-like protein 3 (DLL3) is a ligand for the Notch signaling pathway and inhibits primary neurogenesis. It plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.
Defects in DLL3 cause Spondylocostal dysostosis autosomal recessive type 1 (SCDO1), leading to truncal shortening, abdominal protrusion, abnormal spinal curvature, and occasionally plagiocephaly-torticollis sequence.
DLL3 may be required to divert neurons along a specific differentiation pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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