Thermo Fisher Scientific MD-2 Monoclonal Antibody (18H10), FITC

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

1:50

-

Functional Assay (Functional)

1:50

-

Product Specifications

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

18H10

Immunogen

TLR4/MD-2 expressing CHO cells/ chimeric TLR4/MD-2 fusion protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:MD-2,uniProtId:Q9Y6Y9-1,ncbiNodeId:9606,antigenRange:1-160,antigenLength:160,antigenImageFileName:MA5-49060_MD-2_Q9Y6Y9-1_House_mouse.svg,antigenImageFileNamePDP:MA5-49060_MD-2_Q9Y6Y9-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

FITC FITC FITC

View additional formats

• Unconjugated
• Request custom conjugation

Excitation/Emission Max

498/517 nm View spectra

Form

Liquid

Concentration

100 µg/mL

Storage conditions

4° C, store in dark

Shipping conditions

Wet ice

Product Specific Information

The monoclonal antibody 18H10 reacts with MD-2. However, it does not react with sMD-2. In addition, the monoclonal antibody 18H10 is able to inhibit bacterial binding to MD-2.

Target Information

MD-2 is a gene that encodes a protein involved in the recognition of bacterial lipopolysaccharides (LPS) by the immune system. It is located on chromosome 8 and is part of a larger family of genes that encode for similar proteins. The MD-2 protein forms a complex with Toll-like receptor 4 (TLR4) to recognize and respond to LPS, triggering an immune response. Mutations or variations in the MD-2 gene have been associated with various diseases and conditions, including sepsis and inflammatory disorders.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.