Thermo Fisher Scientific LAT Polyclonal Antibody
LAT 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human 시료에 반응합니다. Western blot과 ELISA에 적합하며, 세포막 단백질 LAT의 신호전달 연구에 유용합니다. 액상 형태로 제공되며, -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 95–262 of human LAT (NP_055202.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.48 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914507 |
Product Specific Information
- Positive test controls include: THP-1
- Subcellular localization: Cell membrane, Single-pass type III membrane protein
Immunogen sequence:
PSSRRDSDGA NSVASYENEG ASGIRGAQAG WGVWGPSWTR LTPVSLPPEP ACEDADEDED DYHNPGYLVV LPDSTPATST AAPSAPALST PGIRDSAFSM ESIDDYVNVP ESGESAEASL DGSREYVNVS QELHPGAAKT EPAALSSQEA EEVEEEGAPD YENLQELN
Target Information
LAT (Linker for Activation of T cells) is a 36–38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells, and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell and FcεRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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