Thermo Fisher Scientific LAT Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 95-262 of human LAT (NP_055202.1). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:LAT,uniProtId:O43561-1,ncbiNodeId:9606,antigenRange:95-262,antigenLength:262,antigenImageFileName:PA5-120935_LAT_O43561-1_Rabbit.svg,antigenImageFileNamePDP:PA5-120935_LAT_O43561-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.48 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.09% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2914507

Product Specific Information

Positive test controls include: THP-1. The target is usually found in the following locations: Cell membrane, Single-pass type III membrane protein.

Immunogen sequence: PSSRRDSDGA NSVASYENEG ASGIRGAQAG WGVWGPSWTR LTPVSLPPEP ACEDADEDED DYHNPGYLVV LPDSTPATST AAPSAPALST PGIRDSAFSM ESIDDYVNVP ESGESAEASL DGSREYVNVS QELHPGAAKT EPAALSSQEA EEVEEEGAPD YENLQELN

Target Information

LAT (Linker for Activation of T cells) is a 36-38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell- and FcepsilonRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.