Thermo Fisher Scientific Phospho-BCL-2 (Thr56) Polyclonal Antibody
Phospho-BCL-2 (Thr56) 폴리클로날 항체로, 세포 내 BCL-2 단백질의 Thr56 인산화 상태를 검출합니다. Western blot 및 IHC(P) 실험에 적합하며, 인간 및 생쥐 시료에 반응합니다. 항원 친화 크로마토그래피로 정제된 고품질 항체입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide derived from epitope -GHTPH- with the phosphorylation site Thr56 of human BCL-2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | 25mM Tris with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: UV-treated Raji cells
- Cellular location: Cytoplasmic, Mitochondrial membrane
Target Information
BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. The BCL-2 family members dimerize to modulate apoptosis. Bag1 forms a heterodimer with BCL-2, enhancing its anti-apoptotic effect. Bax and Bak promote cytochrome c release from mitochondria, initiating apoptosis. Constitutive expression of BCL-2, such as in translocation to the Ig heavy chain locus, is associated with follicular lymphoma. Overexpression of BCL-2 has been linked to human cancers including B-cell lymphoma and prostate cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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