Thermo Fisher Scientific Phospho-TSC2 (Ser664) Polyclonal Antibody
TSC2 단백질의 Ser664 인산화 상태를 특이적으로 인식하는 rabbit polyclonal antibody. Western blot에 적합하며, 인간 및 생쥐 시료에서 반응. 1 mg/mL 액상 형태로 제공되며, PBS/glycerol buffer에 보관. 종양 억제 단백질 연구에 유용.
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Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TSC2 (Accession P49815), corresponding to amino acid residues around phosphorylated Ser664. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816651 |
Product Specific Information
Antibody detects endogenous levels of Tuberin/TSC2 only when phosphorylated at Ser664.
Target Information
TSC2 (Tuberin, Tuberous sclerosis complex, TSC Complex Subunit 2) is a tumor suppressor protein involved in vesicular transport, regulation of cell growth arrest, and transcription mediated by steroid receptors.
TSC2 forms a cytosolic complex with hamartin, potentially acting as a chaperone. Phosphorylation at Ser939 and Thr1462 regulates the TSC2-hamartin interaction via the PI3K/Akt pathway.
TSC2 stimulates the intrinsic GTPase activity of RAP1A and RAB5, contributing to cell growth regulation.
Mutations in TSC2 are associated with diseases such as lymphangioleiomyomatosis and TSC2 angiomyolipoma. Alternative splicing produces multiple isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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