Thermo Fisher Scientific Caspase 7 (Cleaved Asp198) Polyclonal Antibody
Caspase 7 (Cleaved Asp198) 특이적 폴리클로날 항체로, 인간 및 생쥐 시료에서 활성형 Caspase 7 단편을 검출. Western blot에 최적화되어 있으며, 고순도의 Affinity chromatography 정제 항체. 세포사멸 연구용으로 적합.
- 카탈로그번호
- PA5114688
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CASP7 (Accession P55210), corresponding to amino acid residues P178–A207 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2899324 |
Product Specific Information
This antibody detects endogenous levels of the activated Caspase 7 fragment resulting from cleavage adjacent to Asp198.
Target Information
Caspase 7 belongs to the family of cysteine proteases, divided into apoptotic and inflammatory subfamilies. Apoptotic caspases include initiator and executioner types; Caspase 7 functions as an executioner caspase, activated by initiator caspases to cleave cellular substrates leading to apoptosis.
It shares homology with caspases 1 and 3 and the C. elegans protein CED-3.
Alternative splicing of Caspase-7 mRNA produces multiple isoforms. Caspase-7 activity can be inhibited by XIAP expression.
Diseases associated with CASP7 include Type 1 Diabetes Mellitus 17 and Aleutian Mink Disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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