Thermo Fisher Scientific TGM2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.05–0.2 µg/mL
• Publications: -

Product Specifications

Product Specific Information

• This antibody is expected to recognize isoform a (NP_004604.2) only.
• Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.

Target Information

Transglutaminase (TGase) catalyzes the crosslinking of proteins by forming ε-(γ-glutamyl) lysine isopeptide bonds and requires Ca²⁺ binding for its activity.
In mammals, eight distinct TGase isoenzymes have been identified.
Tissue transglutaminase (tTGase), also known as TGase 2, consists of four domains: N-terminal β-sandwich, catalytic core, and two C-terminal β-barrel domains.
tTGase may play roles in cell death, proliferation, differentiation, and receptor-mediated endocytosis.
In Alzheimer’s disease, elevated tTGase activity contributes to polymerization of proteins such as Aβ peptide, β-amyloid precursor protein, and tau, leading to neurofibrillary tangle formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.