Thermo Fisher Scientific TGM2 Polyclonal Antibody
TGM2 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체. Western blot에 적합하며, 인간 시료 반응성. 0.5 mg/mL 농도의 액상 형태로 제공되며, -20°C에서 보관. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-ESDKLKAVKGFRN |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2932925 |
Product Specific Information
- This antibody is expected to recognize isoform a (NP_004604.2) only.
- Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
Transglutaminase (TGase) catalyzes the crosslinking of proteins by forming ε-(γ-glutamyl) lysine isopeptide bonds and requires Ca²⁺ binding for its activity.
In mammals, eight distinct TGase isoenzymes have been identified.
Tissue transglutaminase (tTGase), also known as TGase 2, consists of four domains: N-terminal β-sandwich, catalytic core, and two C-terminal β-barrel domains.
tTGase may play roles in cell death, proliferation, differentiation, and receptor-mediated endocytosis.
In Alzheimer’s disease, elevated tTGase activity contributes to polymerization of proteins such as Aβ peptide, β-amyloid precursor protein, and tau, leading to neurofibrillary tangle formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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