Thermo Fisher Scientific MYLK Polyclonal Antibody
Human MYLK 단백질을 인식하는 Goat Polyclonal Antibody로, Western blot에 적합합니다. 0.5 mg/mL 농도의 액상 형태이며, TBS(pH 7.3) + 0.5% BSA로 보존됩니다. 모든 보고된 MYLK isoform을 인식하며, 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.01–0.03 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-KDTKNMEAKKLSKD |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2932927 |
Product Specific Information
- This antibody is expected to recognize all reported isoforms (NP_444253.3, NP_444254.3, NP_444255.3, NP_444256.3).
- Tested in Peptide ELISA: antibody detection limit dilution 1:8,000.
Target Information
MYLK (Myosin Light Chain Kinase, MLCK)
MYLK is a serine/threonine kinase that phosphorylates myosin regulatory light chains to promote contractile activity through myosin–actin interaction.
It plays a critical role in smooth muscle contraction, vascular permeability, and tissue edema formation.
In the nervous system, MYLK regulates astrocytic process growth and neurotransmitter release at sympathetic synapses.
It is also involved in fibroblast apoptosis signaling pathways.
Smooth muscle and non-muscle isoforms are expressed in various tissues, with non-muscle isoform 2 being dominant.
The Telokin isoform binds calmodulin and is present in adult and fetal tissues.
MYLK contains one fibronectin type III domain and nine immunoglobulin-like C2-type domains and is likely down-regulated by phosphorylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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