Thermo Fisher Scientific CHD5 Polyclonal Antibody
CHD5 단백질을 인식하는 염소 유래 폴리클로날 항체로, 인간 시료에 반응합니다. ICC/IF 및 유세포분석(Flow Cytometry)에 적합하며, 고순도의 액상 형태로 공급됩니다. 신경계 발달 및 종양 억제 관련 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-QSRRQLKSDRDKP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2932920 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:64,000.
Target Information
CHD5 (Chromodomain helicase DNA binding protein 5) is a member of the SNF2/RAD54 helicase family of chromatin remodeling and DNA-binding proteins (CDH proteins). It is heavily expressed in both fetal and adult brain, playing a crucial role in nervous system development and acting as a tumor suppressor via the Arf/p53 pathway.
CHD5, along with other chromodomain proteins, forms remodeling complexes such as NuRD that promote normal neuroblast maturation and prevent overexpression of neuronal cells. Disruptions in these complexes can maintain cells in a proliferative state, leading to tumor formation.
Deletions in the CHD5 gene are commonly found in neuroblastomas, suggesting that CHD5 deficiency may contribute to malignant transformation and metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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