Thermo Fisher Scientific Perforin-1 (Pore Forming Protein) (Apoptosis Marker) Recombinant Rabbit Monoclonal Antibody (PRF1/7077R)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Assay-dependent

Immunohistochemistry (PFA fixed) (IHC (PFA))

• 1–2 µg/mL

Product Specifications

Target Information

Perforin is one of the major cytolytic proteins found in cytolytic granules. It acts as a cytolytic mediator stored in and released by cytoplasmic granules and plays a key role in immune defense against tumors and viral infections mediated by cytotoxic lymphocytes.
Perforin is a 555 amino acid protein with a 21 amino acid signal peptide, having a molecular weight of 70–75 kDa. It forms transmembrane channels similar to complement component C9, with demonstrated homology between perforin and C9.
Expression is restricted to killer cell lines and absent in helper T lymphocytes or other tumor cells. Defects in the perforin gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood.
Alternative splicing results in multiple transcript variants of perforin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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