Thermo Fisher Scientific CD200 Receptor Monoclonal Antibody (OX108), eBioscience
인간 CD200R(OX2) 인식 단클론 항체로, Flow Cytometry에 최적화됨. OX108 클론, Mouse IgG1, 비결합형. 0.5 mg/mL 액상 형태로 PBS(pH 7.2)에 0.09% sodium azide 포함. 4°C 보관, 친화 크로마토그래피로 정제.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Flow Cytometry (Flow) | 0.5 µg/test |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published species | Not Applicable |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OX108 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1210466 |
Additional Formats
Product Specific Information
Description:
The monoclonal antibody OX108 recognizes human CD200R (also known as OX2). CD200R is an inhibitory receptor structurally similar to its ligand CD200 but lacks a typical ITIM domain. Instead, its cytoplasmic domain contains a phosphotyrosine binding domain (NPXY) that interacts with SHIP to inhibit ERK, JNK, and MAPK p38 pathways, leading to suppression of TNFα secretion in activated macrophages. CD200R isoforms are implicated in immune tolerance, particularly in tolerogenic dendritic cells.
Expression is restricted to hematopoietic cells, including myeloid cells (monocytes, macrophages, dendritic cells, neutrophils, mast cells, and basophils), subsets of T lymphocytes, Langerhans cells, and dendritic epidermal T cells. The OX108 epitope is thought to be near the CD200 binding site.
Applications Reported:
- Flow cytometric analysis
Applications Tested:
- Tested by flow cytometric analysis of normal human peripheral blood cells
- Recommended ≤0.5 µg per test (100 µL final volume, 10⁵–10⁸ cells/test)
- Optimize antibody titration for best assay performance
Purity: >90% (SDS-PAGE)
Aggregation: <10% (HPLC)
Filtration: 0.2 µm post-manufacturing filtered
Target Information
CD200R (OX2R) is a receptor for the OX-2 membrane glycoprotein. Both receptor and ligand are cell surface glycoproteins with two immunoglobulin-like domains. CD200R is mainly expressed on myeloid lineage cells and mediates downregulation of myeloid activity. In mice, it is found on monocytes, neutrophils, T-lymphocytes, and mast cells. Alternative splicing results in multiple transcript variants, and CD200R dysfunction is associated with primary hypertrophic osteoarthropathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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