Thermo Fisher Scientific PUM1 Recombinant Rabbit Monoclonal Antibody (8H60L23)
PUM1 단백질을 인식하는 재조합 토끼 단일클론 항체로, Western blot에 최적화됨. Human과 Mouse에 반응하며, Rat과 Bovine에도 예측 반응. Protein A로 정제된 액상 항체로, 안정적 보관 및 높은 특이성 제공.
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Applications
- Western Blot (WB): Tested dilution 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 8H60L23 |
| Immunogen | Protein corresponding to human PUM1 (aa229–aa370) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2811731 |
Product Specific Information
This antibody is predicted to react with Rat and Bovine.
Target Information
PUM1 (pumilio homolog 1) is a sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3′-UTR of mRNA targets. It is part of the PUF family of evolutionarily conserved RNA-binding proteins. PUM1 binds to the RNA consensus sequence known as the Pumilio Response Element (PRE, 5′-UGUANAUA-3′), related to the Nanos Response Element (NRE).
PUM1 mediates post-transcriptional repression of transcripts via mechanisms involving recruitment of the CCR4-POP2-NOT deadenylase complex, leading to translational inhibition and mRNA degradation. Mutations in the PUM1 gene can result in spinocerebellar ataxia 47.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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