Thermo Fisher Scientific TAB1 Recombinant Rabbit Monoclonal Antibody (21H11L15)
TAB1 단백질을 인식하는 재조합 토끼 단일클론 항체로, Western blot에 최적화되어 있습니다. 인간 및 생쥐 반응성을 가지며, 높은 특이성과 일관성을 제공합니다. Protein A로 정제된 액상 형태로, 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications
- Western Blot (WB): 1:500 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 21H11L15 |
| Immunogen | Protein corresponding to human TAB1 (aa1–aa370) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2784571 |
Product Specific Information
This antibody is predicted to react with Monkey, Pig, and Dog.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) regulates MAP3K7/TAK1, which mediates intracellular signaling pathways induced by TGF beta, IL-1, and WNT-1. TAB1 activates TAK1 kinase through interaction, with its C-terminal portion sufficient for activation and N-terminal portion acting as a dominant-negative inhibitor. TAB1 also interacts with MAPK14/p38α, providing an alternative activation pathway contributing to MAPK14 biological responses.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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