Thermo Fisher Scientific Phospho-Catenin alpha-1 (Tyr177) Polyclonal Antibody
Rabbit polyclonal antibody recognizing phosphorylated alpha-1 catenin (Tyr177). Validated for Western blot at 1:500–1:2,000 dilution. Detects endogenous phosphorylated protein only. Supplied as liquid, 1 mg/mL, stored at -20°C. For research use only.
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Applications
- Western Blot (WB): Tested dilution 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CTNNA1 (Accession P35221), corresponding to amino acid residues around phosphorylated Tyr177 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816991 |
Product Specific Information
This antibody detects endogenous levels of alpha-1 catenin only when phosphorylated at Tyr177.
Target Information
Alpha-1 catenin associates with the cytoplasmic domain of various cadherins. The catenin–cadherin complex links to the actin filament network, playing a key role in cadherin-mediated cell adhesion. It can associate with both E- and N-cadherins. Initially thought to mediate cadherin–actin linkage, later studies suggest CTNNA1 does not bind F-actin in the complex, implying a distinct mechanism for actin–adherens junction interaction. The homodimeric form may regulate actin filament assembly and inhibit branching by competing with the Arp2/3 complex. It is potentially crucial for cell differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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