Thermo Fisher Scientific CD365 (TIM1) Monoclonal Antibody (RMT1-10)

Applications and Tested Dilutions

Product Specifications

Available Conjugated Formats

• FITC
• PE
• Request custom conjugation

Product Specific Information

Rat anti-Mouse TIM-1 antibody (clone RMT1-10) recognizes mouse Tim-1 (T-cell immunoglobulin mucin 1), a cell surface glycoprotein belonging to the immunoglobulin superfamily. Tim-1 was first identified as the hepatitis A virus cellular receptor (HAVCR) and is highly expressed in the liver (isoform Tim-1a) and kidneys (isoform Tim-1b).

Target Information

CD365, also known as T-cell immunoglobulin and mucin domain 1 (Tim-1), is a type I surface glycoprotein composed of an extracellular N-terminal immunoglobulin V-like domain, a mucin domain, and a short cytoplasmic tail. The endogenous ligand for CD365 is Tim-4.

CD365 acts as a receptor or co-receptor for several viruses including hepatitis A and C, Ebola, Marburg, Dengue, Zika, West Nile, and Japanese encephalitis viruses. Viral binding occurs via phosphatidylserine exposed on viral envelopes. Polymorphisms in the human CD365 gene (HAVCR1) are associated with infection susceptibility and disease severity. CD365 is implicated in T-cell co-stimulation and is primarily expressed in epithelial cells, with high expression in A549, 769-P, and Caco-2 cell lines. A soluble form of CD365 is generated by metalloproteinase-mediated cleavage.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.