Thermo Fisher Scientific CD365 (TIM1) Monoclonal Antibody (RMT1-10), FITC
Flow Cytometry용 FITC-conjugated mouse CD365 (TIM-1) 단클론 항체. Rat IgG2a 유래로 높은 특이성과 재현성 제공. Protein A 정제, PBS + 1% BSA buffer, 4°C 단기 보관. 바이러스 수용체 연구 및 T세포 공동자극 연구에 적합.
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Applications
- Flow Cytometry (Flow)
Tested Dilution: Neat–1:10
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | RMT1-10 |
| Immunogen | Full-length mouse Tim-1-Ig, containing both the IgV and mucin domains of Tim-1 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745179 |
Additional Formats
- Unconjugated (MA5-28211)
- PE (MA5-28210)
- Custom conjugation available upon request
Product Specific Information
Rat anti-Mouse TIM-1 antibody, clone RMT1-10 recognizes mouse Tim-1 (T-cell immunoglobulin mucin 1), a cell surface glycoprotein and member of the immunoglobulin superfamily. TIM-1 was first identified as the hepatitis A virus cellular receptor (HAVCR) and is highly expressed in the liver (isoform Tim-1a) and kidneys (isoform Tim-1b).
Target Information
CD365, also known as T-cell immunoglobulin and mucin domain 1 (Tim-1), is a type I surface glycoprotein with an extracellular N-terminal immunoglobulin V-like domain, a mucin domain, and a short cytoplasmic tail.
The endogenous ligand for CD365 is Tim-4. CD365 acts as a receptor or co-receptor for several viruses, including hepatitis A and C, Ebola, Marburg, Dengue, Zika, West Nile, and Japanese encephalitis viruses. Virus binding occurs via phosphatidylserine exposed on viral envelopes.
Polymorphisms in the human CD365 gene (HAVCR1) are associated with infection susceptibility and disease severity. CD365 also plays a role in T-cell co-stimulation and is primarily expressed in epithelial cells, with high expression in A549, 769-P, and Caco-2 cell lines. Soluble CD365 can be generated by metalloproteinase-mediated proteolytic cleavage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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