Thermo Fisher Scientific DLL4 (delta-like 4) Monoclonal Antibody (HMD4-2)

Applications and Tested Dilution

Product Specifications

Additional Formats

• PE
• Request custom conjugation

Product Specific Information

Hamster anti-Mouse Delta-Like Protein 4 antibody, clone HMD4-2 recognizes mouse Delta-like protein 4 (DLL4), one of the five major ligands of the Notch signaling pathway, which is activated through the binding of specific ligands to the Notch receptors Notch 1–4.

Target Information

Delta-like ligand 4 (DLL4), also known as Delta-4, is a homologue of the Drosophila delta protein and functions as a transmembrane ligand to the Notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF) as a negative feedback regulator to control angiogenic sprouting and promote the formation of a differentiated vascular network.

DLL4 is strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer. Inhibition of DLL4 leads to increased vascular proliferation but defective maturation, resulting in reduced tumor growth without apparent toxicity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.