Thermo Fisher Scientific IL-13 Monoclonal Antibody (eBio13A), eFluor 450, eBioscience
Mouse IL-13을 인식하는 eBio13A 단클론 항체로, eFluor 450 형광체가 결합된 제품입니다. Flow Cytometry에 적합하며 405/445 nm 파장에서 검출됩니다. 알레르기 염증 및 면역 반응 연구용으로 사용됩니다. 4°C 보관, 동결 금지.
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2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific IL-13 Monoclonal Antibody (eBio13A), eFluor 450, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | 1 publication |
| Flow Cytometry (Flow) | 1 µg/test | 37 publications |
| ELISA | - | 1 publication |
| Neutralization | - | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Rat / IgG1, kappa |
| Recommended Isotype Control | Rat IgG1 kappa Isotype Control (eBRG1), eFluor™ 450 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBio13A |
| Conjugate | eFluor™ 450 |
| Excitation / Emission Max | 405 / 445 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11218502 |
Additional Formats Available
- Unconjugated
- Alexa Fluor 488
- APC-eFluor 780
- Brilliant UV 737
- Brilliant UV 805
- eFluor 660
- Functional Grade
- PE
- PE-Cyanine7
- PE-eFluor 610
- PerCP-eFluor 710
- Custom conjugation available upon request
Product Specific Information
The eBio13A antibody reacts with mouse IL-13, a cytokine mainly produced by Th2 cells and antigen-primed CD8 T cells. IL-13 plays a role in allergic inflammation, parasitic clearance, and cancer-related immune modulation. In humans, IL-13 contributes to B cell isotype switching and down-regulates macrophage activity by reducing pro-inflammatory cytokines (IL-1, IL-6, IL-8, IL-10, IL-12).
Applications Reported: Intracellular staining followed by flow cytometric analysis.
Applications Tested: Intracellular staining and flow cytometric analysis of Th2-polarized mouse splenocytes. Recommended ≤1 µg/test in 100 µL final volume (cell number 10⁵–10⁸ cells/test). Optimize antibody titration for best performance.
Fluorophore Information:
eFluor® 450 is an alternative to Pacific Blue®, excited at 405 nm and emits at 445 nm (Violet laser). Ensure instrument compatibility.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells. It regulates inflammatory and immune responses, down-regulates macrophage activity, and inhibits pro-inflammatory cytokine and chemokine production. IL-13 is implicated in allergen-induced asthma independent of IgE and eosinophils, influences B cell maturation, up-regulates CD23 and MHC class II, and promotes IgE isotype switching.
The IL-13 gene is part of a cytokine cluster on chromosome 5q, close to IL4, IL3, IL5, and CSF2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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